I would like everything that I post to be considered a personal opinion.
I know that it doesn't require a literal hunter-gatherer lifestyle to eat a paleolithic diet, just that with cultivation, there are consequences. If you have a gigantic field of one kind of vegetable and a certain bug comes by to eat them, what can you do? Pesticides aren't very healthy, but it was a good option when it came out. People also thought (and still do think) that genetically altering foods was a good idea. That's why we have organic foods. I personally think that the best option would be to grow your own fruits and vegetables on your own land, but with the world's current population being so high (along with everybody already owning property), it'd be hard for people to move out of close-together housing like apartments and into homes with actual yards. The whole reference to having a city surrounded by a garden is just that, everybody having a certain section of the overall food that they can eat. In my opinion, there would be no need for bread and preservable goods if every city had its own food supply.
As for the vaccination reference, it's a similar conversation, not a different one. I know the chances, 1 in 150, very low if you ask me. I've had a retarded cousin, and I've had a friend with an autistic brother. It's not nice, but imagine, instead of taking care of somebody mentally ill, somebody physically ill. Badly ill. The comparison was one of "the worse of two evils" (if you will), along with the good intentions of others. Nobody wants an autistic child when they think of having kids, but it's just one of those risks, along with birth defects and the such. I feel as if the progression we've made from cultivating grains far outweighs even the cost of a healthier diet, and we have certain things to support it, such as certain drugs to fight off the negative side effects. Being able to keep less-perishable foods and concentrated foods have fought off hunger in exchange for consequences in health, but the overall benefit is that we can actually keep the poor alive! Imagine how hard it would be to have a paleolithic soup kitchen, or to feed entire lunchrooms with these kinds of foods. It truly is too expensive for many to go with, and I really don't want to hear "well, what if the gov't subsidized it?", because that doesn't seem to be working very well in the corn industry.
My personal opinion is that the societal benefits of non-natural foods far outweigh the negative side effects. If you want to use hydrogenated oils as an example of successful removal, you still have hormones, steroids, genetic altering and H.F. corn syrup to go. Those things don't have almost any positive effects besides lower costs, and now that we can see the negative effects, they should be rid of. That I can agree in, but overall, I think the paleolithic diet is just one the world's population can't safely support. It's sad that economics have to get in the way of health, but I can only imagine how bad health was in the American Industrial Revolution..